Email Us: Andrea Meredith
Postdoc Position Available to Study KCNMA1-Linked Channelopathy
Our research focuses on the mechanisms by which ion channels regulate information coding in the brain and other excitable cells (http://meredithlab.org). In my lab, we combine the genetic manipulation of ion channels with electrophysiology, imaging, and in vivo physiology. Two central goals of the lab are to identify the fundamental biophysical properties of ion channels that cause neurological diseases, and to identify how ion channels pattern action potential activity in the circadian clock of the brain. Techniques in the lab include voltage- and current-clamp recordings, multi-electrode array recordings, imaging, molecular biology, transgenics, and in vivo telemetry.
For this postdoctoral position, we are seeking a highly motivated team-player to contribute to our studies of a new ion channelopathy defined by mutations in KCNMA1, the gene encoding the large conductance Ca2+-activated BK channel. The project involves investigating human KCNMA1 mutations and their impact on excitability in heterologous and neuronal models. See our recent publications:
- KCNMA1-Linked Channelopathy (Journal of General Physiology, 2019, 151 (10): 1173)
- Comparative Gain-of-Function Effects of KCNMA1-N999S Mutation on Human BK Channel Properties (Journal of Neurophysiology, 2019, ePub ahead of print 18 Dec 2019)
- Effects of single nucleotide polymorphisms in human KCNMA1 on BK current properties (Frontiers in Molecular Neuroscience, 2019, 12:285).
Requirements: Candidates should have a PhD in biophysics, neuroscience, physiology, or other relevant field. Experience with electrophysiological recordings is required. Excellent oral and written communication skills should be demonstrated through publications and presentations. This position will be funded by an NIH T32 training grant, which requires US citizenship or permanent residency.
To apply: Please send your application by email to Dr. Andrea Meredith, including:
– your CV
– a letter describing research accomplishments, expertise, and career goals
– the names and contact information for three references
The Department of Physiology (http://medschool.umaryland.edu/physiology) offers outstanding research and NIH-funded postdoctoral training opportunities. The University of Maryland School of Medicine, located in downtown Baltimore, is the oldest public medical school in the U.S. and the founding campus of the University of Maryland system. The School of Medicine ranks 6th among all 76 public medical schools.
Lab Alumni and Current Positions:
Jenna Montgomery: Senior Scientist, Electrophysiology,
Cerevance, Cambridge, UK
Chris Shelley: Assistant Professor, University of the South, Sewanee, TN
Rachel White: Postdoc at U. Penn
Graduate Students: Mike Lai: Scientist at The Gladstone Institute (Mission Bay, UCSF)
Josh Whitt: Postdoc at Brown
Betsy Zemen: University of Central Florida (PhD Program)
Breanne Wright: Purdue (PhD Program)
Benyam Kinde: Harvard (MD/PhD program)
Grace Silva: UNC (PhD Program)
Jack Kent: Chief Commercialization Officer, Coaptech Medical Devices