TRANSGENIC MOUSE LINES
Transnetyx (automated assays for genotyping our transgenic lines)
Kcnma1–/– mice (global BK channel knockout)
Description of Kcnma1-/- mice: Meredith AL, Thorneloe KS, Werner ME, Nelson MT, and Aldrich RW (2004). Overactive bladder and incontinence in the absence of the BK Ca2+-activated K+ channel. Journal of Biological Chemistry 279:36746-36752.
http://www.ncbi.nlm.nih.gov/pubmed/15184377
PCR Genotyping Protocol for Kcnma1–/–
Tg-BKR207Q mice (gain-of-function BK channel transgenic)
Kcnma1fl (conditional BK channel knockout, coming soon)
SUPPLEMENTAL DATA
Mis-expression of the BK K+ channel disrupts suprachiasmatic nucleus circuit rhythmicity and alters clock-controlled behavior. AJP- Cell Physiology 304: C299-C311 (2013).
GENBANK CLONES (Genbank Accession Links Coming Soon)
– Tg-BKR207Q (JX429072)
– SCN Variant SCN-C5b (JX462785)
– SCN Variant SCN-C5b:YFP (JX462786)
– mbr5