Email Us: Andrea Meredith
Postdocs: Ria Dinsdale, Hans Moldenhauer, Su Mi Park, Jenna Montgomery (Harvey)
Research Associates: Hans Moldenhauaer
Grad Students: Cooper Roache, Katia Matychak, Amber Plante, Mike Lai, Josh Whitt
Prism Medical Fellows: Indira Jetton, Jacob Miller, Cole Bailey
Undergrads: Kelly Tammen, Zulqarnain Khan, Jessica Lu
Postdoc Position Available to Study KCNMA1-Linked Channelopathy (Sept 2022)
Our research focuses on the mechanisms by which ion channels regulate information coding in the brain and other excitable cells. In my lab, we combine the genetic manipulation of ion channels with electrophysiology, imaging, and in vivo physiology. Two central goals of the lab are to identify the fundamental biophysical properties of ion channels that cause neurological diseases, and to identify the ion channel basis for state-dependent changes in action potential activity in the circadian clock of the brain. Techniques in the lab include voltage- and current-clamp recordings, multi-electrode array recordings, imaging/FRET, molecular biology, transgenics, and in vivo telemetry.
For this postdoctoral position, we are seeking a highly motivated team-player to contribute to our studies of a new ion channelopathy defined by mutations in KCNMA1, the gene encoding the large conductance Ca2+-activated BK channel. The project involves investigating KCNMA1 channelopathy patient mutations and their impact on BK currents in heterologous cells and neuronal excitability in mouse models. See our recent publications:
- Park SM, Roache CE, Iffland PH, Moldenhauer HJ, Matychak KK, Plante AE, Lieberman AG, Crino PB, and Meredith AL (2022). BK channel properties correlate with neurobehavioral severity in three KCNMA1-linked channelopathy mouse models. eLife 2022;11:e77953.
- Miller, J, Moldenhauer, HJ, Keros, S, Meredith, AL (2021). An Emerging Spectrum of Variants and Clinical Features in KCNMA1-Linked Channelopathy. Channels 15(1):447‑464.
- Moldenhauer, HJ, Matychak, K, and Meredith, AL (2020). Comparative Gain-of-Function Effects of KCNMA1-N999S Mutation on Human BK Channel Properties. Journal of Neurophysiology 123:560.
Requirements: Candidates should have a PhD in biophysics, neuroscience, physiology, or other relevant field. Experience with electrophysiological recordings is required. Excellent oral and written communication skills should be demonstrated through publications and presentations.
To apply: Please send your application by email to Dr. Andrea Meredith, including:
- your CV
- a letter describing research accomplishments, expertise, and career goals
- the names and contact information for three references
The Department of Physiology offers outstanding research and NIH-funded postdoctoral training opportunities. The University of Maryland School of Medicine, located in downtown Baltimore, is the oldest public medical school in the U.S. and the founding campus of the University of Maryland system. The School of Medicine ranks 6th among all 76 public medical schools.
Lab Alumni and Current Positions
- Hans Moldenhauer: Researcher at the Millennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Santiago, Chile (and Research Associate in the lab)
- Jenna Montgomery: Principle Scientist, Electrophysiology
- Cerevance, Cambridge, UK
- Chris Shelley: Assistant Professor, University of the South, Sewanee, TN
- Rachel White: Research Associate at U. Penn
- Cooper Roache
- Katia Matychak
- Mike Lai: Scientist at The Gladstone Institute (Mission Bay, UCSF)
- Josh Whitt: Postdoc at Brown
- Kelly Tammen
- Betsy Zemen: University of Central Florida (PhD Program)
- Breanne Wright: Purdue (PhD Program)
- Benyam Kinde: Harvard (MD/PhD program)
- Grace Silva: UNC (PhD Program)
- Jack Kent: Chief Commercialization Officer, Coaptech Medical Devices